271-OR: Whole-Exome Sequence Identifies Potentially Functional Rare Variants in Bardet-Biedl Syndrome (BBS) Genes that Associate with Obesity in American Indians

American Indians suffer from a high prevalence of obesity. Although their obesity is typically polygenic in nature, we are systematically analyzing known monogenic obesity genes in a population-based sample of Pima Indians. Previously, we have reported that 3% of this population carries functional mutations in MC4R. The goal of the current study is to determine whether variation in any of the 21 known BBS genes also contribute to obesity in this...