Prognostic impact of tristetraprolin (TTP) and PTEN loss and assessment of associated immune infiltrates in localized prostate cancer (PrCa).

e16601 Background: We previously showed that loss of PTEN by quantitative multiplex immunofluorescence (qIF) is associated with relapse after prostatectomy. Low expression of TTP, which modulates the NF-kB pathway and inflammation, is prognostic for lethal PrCa after surgery. We also showed, with this assay, that low CD8+ density is a poor prognostic marker. We hypothesized that co-loss of these independent cell signaling regulators leads to...