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Developmental transcriptomics of Chinese cordyceps reveals gene regulatory network and expression profiles of sexual development-related genes

Published on Dec 1, 2019in BMC Genomics 3.50
· DOI :10.1186/s12864-019-5708-z
Xiao Li (CAS: Chinese Academy of Sciences), Fen Wang2
Estimated H-index: 2
(CAS: Chinese Academy of Sciences)
+ 6 AuthorsCaihong Dong10
Estimated H-index: 10
(CAS: Chinese Academy of Sciences)
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Abstract
Background Chinese cordyceps, also known as Chinese caterpillar fungus (Ophiocordyceps sinensis, syn. Cordyceps sinensis), is of particular interest for its cryptic life cycle and economic and ecological importance. The large-scale artificial cultivation was succeeded recently after several decades of efforts and attempts. However, the induction of primordium, sexual development of O. sinensis and the molecular basis of its lifestyle still remain cryptic.
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Published on Feb 17, 2019in Critical Reviews in Biotechnology 7.05
Xiao Li (CAS: Chinese Academy of Sciences), Qing Liu1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences)
+ 4 AuthorsCaihong Dong10
Estimated H-index: 10
(CAS: Chinese Academy of Sciences)
AbstractChinese cordyceps, an entity of the Chinese caterpillar fungus (Ophiocordyceps sinensis, syn. Cordyceps sinensis) that parasitizes ghost moth larvae, is one of the best known traditional Chinese medicines and is found exclusively on the Tibetan Plateau with limited natural resources. Although the fungus O. sinensis can grow on artificial substrates and the ghost moth has been successfully reared, the large-scale artificial cultivation of Chinese cordyceps has only recently been accomplis...
Published on Oct 1, 2018in Fungal Biology 2.70
Xin Zhong5
Estimated H-index: 5
(SYSU: Sun Yat-sen University),
Li Gu3
Estimated H-index: 3
(SYSU: Sun Yat-sen University)
+ 7 AuthorsXin Liu8
Estimated H-index: 8
(SYSU: Sun Yat-sen University)
Abstract Ophiocordyceps sinensis , a Chinese complementary and alternative medicine (CAM), is an entomopathogenic, fungus, parasitizing larvae of the moth genus Thitarodes . It has three stages of the life cycle, i.e., the anamorph mycelia prior to infection (Cm_Os), the mycelia sclerotium forming in the caterpillar (Te_Ca), and the fruiting bodies or stromata (Te_St). Characterization of the O . sinensis transcriptome among these stages could provide a better understanding of the underlying bio...
Published on Aug 31, 2018in Bioscience Reports 2.54
Hui Liu (Biotechnology Institute), Shilei Sang (JNU: Jinan University)+ 5 AuthorsYongxiang Liu (Biotechnology Institute)
Aspergillus cristatus belongs to the homothallic fungal group that undergoes a sexual stage without asexual conidiation under hypotonic conditions, while hypertonic medium induces initiation of the asexual stage and completely blocks sexual development. However, the veA deletion mutant only produces conidia in hypotonic medium after a 24 h culture, but both asexual and sexual spores are observed after 72 h. To elucidate the molecular mechanism of how VeA regulates asexual and sexual spore develo...
Published on May 1, 2018
SiWei Zhang (CAS: Chinese Academy of Sciences), Kai Cen5
Estimated H-index: 5
(CAS: Chinese Academy of Sciences)
+ 2 AuthorsChengshu Wang38
Estimated H-index: 38
(CAS: Chinese Academy of Sciences)
The caterpillar fungus (i.e., the insect-fungus complex) is formed when the ghost moth ( Thitarodes spp.) larvae have been infected and killed by the fungus Ophiocordyceps sinensis . After finishing the genomics study of O. sinensis , we performed metatranscriptomics analysis of the caterpillar fungal samples collected from five places within the Qinghai-Tibetan Plateau. The fruiting-bodies were dissected for total RNA isolation and RNA-seq analysis. It was found that diversified microbial commu...
Published on Mar 7, 2018in Toxins 3.90
Ji Young Shin3
Estimated H-index: 3
,
Jung-Eun Kim21
Estimated H-index: 21
+ 1 AuthorsHokyoung Son14
Estimated H-index: 14
Cytochrome P450s (CYPs), heme-containing monooxygenases, play important roles in a wide variety of metabolic processes important for development as well as biotic/trophic interactions in most living organisms. Functions of some CYP enzymes are similar across organisms, but some are organism-specific; they are involved in the biosynthesis of structural components, signaling networks, secondary metabolisms, and xenobiotic/drug detoxification. Fungi possess more diverse CYP families than plants, an...
Published on Feb 14, 2018in Genes 3.33
Li Yin1
Estimated H-index: 1
,
Zhihui Cai1
Estimated H-index: 1
+ 1 AuthorsCunshuan Xu1
Estimated H-index: 1
Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms of development remain elusive due to its complexity. To explore the stepwise carcinogenic process from pre-neoplastic lesions to the end stage of HCC, we employed weighted gene co-expression network analysis (WGCNA) which has been proved to be an effective method in many diseases to detect co-expressed modules and hub genes using eight pa...
Published on Dec 1, 2017in Scientific Reports 4.01
Xi-Hui Du4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences),
Qi Zhao8
Estimated H-index: 8
(CAS: Chinese Academy of Sciences)
+ 3 AuthorsZhu L. Yang21
Estimated H-index: 21
(CAS: Chinese Academy of Sciences)
Morchella species are well known world-round as popular and prized edible fungi due to their unique culinary flavor. Recently, several species have been successfully cultivated in China. However, their reproductive modes are still unknown, and their basic biology needs to be elucidated. Here, we use the morel genome information to investigate mating systems and life cycles of fourteen black morel species. Mating type-specific primers were developed to screen and genotype ascospores, hymenia and ...
Published on Dec 1, 2017in Chemistry & Biology
Yongliang Xia7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences),
Feifei Luo4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences)
+ 3 AuthorsChengshu Wang38
Estimated H-index: 38
(CAS: Chinese Academy of Sciences)
Summary Cordycepin (COR) and pentostatin (PTN) are adenosine analogs with related bioactivity profiles as both mimic adenosine and can inhibit some of the processes that are adenosine dependent. Both COR and PTN are also natural products and were originally isolated from the fungus Cordyceps militaris and the bacterium Streptomyces antibioticus , respectively. Here, we report that not only is PTN produced by C. militaris but that biosynthesis of COR is coupled with PTN production by a single gen...
Published on Dec 1, 2017in Scientific Reports 4.01
En-Hua Xia12
Estimated H-index: 12
(CAS: Chinese Academy of Sciences),
Darong Yang1
Estimated H-index: 1
(XTBG: Xishuangbanna Tropical Botanical Garden)
+ 14 AuthorsYan Tong5
Estimated H-index: 5
(CAS: Chinese Academy of Sciences)
To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred ~38 million years ago in concert with the uplift of the plateau. We also observe massive rem...
Published on Sep 1, 2017in Plant Journal 5.73
Rohini Garg19
Estimated H-index: 19
(Shiv Nadar University),
Vikash K. Singh8
Estimated H-index: 8
+ 2 AuthorsMukesh K. Jain64
Estimated H-index: 64
(JNU: Jawaharlal Nehru University)
Seed development is an intricate process regulated via a complex transcriptional regulatory network. To understand the molecular mechanisms governing seed development and seed size/weight in chickpea, we performed a comprehensive analysis of transcriptome dynamics during seed development in two cultivars with contrasting seed size/weight (small seeded, Himchana 1 and large-seeded, JGK 3). Our analysis identified stage-specific expression for a significant proportion (>13%) of the genes. About on...
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