Original paper
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells
Abstract
Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity‐enhancing mutations into their B‐cell receptor genes. Somatic mutagenesis and class switch recombination (CSR) in germinal centre B cells are initiated by the activation‐induced cytidine deaminase ( AID ). Upon germinal centre exit, B cells differentiate into antibody‐secreting plasma cells. Germinal centre maintenance and terminal fate...
Paper Details
Title
Published Date
Jun 3, 2019
Journal
Volume
286
Issue
18
Pages
3566 - 3581
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Notes
History