Original paper

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Volume: 10, Issue: 1
Published: May 15, 2019
Abstract
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique pharmacokinetic characteristics. OPC-163493 shows a good bioavailability upon oral administration and primarily distributed to specific organs: the...
Paper Details
Title
Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Published Date
May 15, 2019
Volume
10
Issue
1
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