High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

Key points Maternal obesity has been associated with shifts in intestinal microbiota, which may contribute to impaired barrier function Impaired barrier function may expose the placenta and fetus to pro‐inflammatory mediators We investigated the impacts of diet‐induced obesity in mice on maternal and fetal intestinal structure and placental vascularization Diet‐induced obesity decreased maternal intestinal short chain fatty acids and their...