Deborah M. Sloboda
McMaster University
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Publications 187
#1Hazel Inskip (Southampton General Hospital)H-Index: 60
#2Keith M. Godfrey (Southampton General Hospital)H-Index: 75
Last. Lucilla Poston ('KCL': King's College London)H-Index: 81
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#1Michelle Saoi (McMaster University)H-Index: 3
#2Katherine M. Kennedy (McMaster University)H-Index: 2
Last. Philip Britz-McKibbin (McMaster University)H-Index: 27
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The placenta is a metabolically active interfacial organ that plays crucial roles in fetal nutrient delivery, gas exchange and waste removal reflecting dynamic maternal and fetal interactions during gestation. There is growing evidence that the sex of the placenta influences fetal responses to external stimuli in utero, such as changes in maternal nutrition and exposure to environmental stressors. However, the exact biochemical mechanisms associated with sex-specific metabolic adaptations during...
Maternal undernutrition decreases sperm production in male offspring, possibly through insulin-like growth factor (IGF-I). To test this hypothesis, we fed pregnant Wistar rats ad libitum with a standard diet (CONTROL) or fed 50% of CONTROL intake, either throughout pregnancy (UNP), lactation (UNL, or both (UNPL). After weaning, male offspring (n = 10 per treatment) were fed a standard diet until postnatal day 160, when testes process for histological and molecular analyses. IGF-I immunostaining ...
#1Luseadra McKerracher (McMaster University)H-Index: 4
#2Tina Moffat (McMaster University)H-Index: 11
Last. Deborah M. SlobodaH-Index: 1
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Environmental factors affecting development through embryogenesis, pregnancy, and infancy impact health through all subsequent stages of life. Known as the Developmental Origins of Health and Disease (DOHaD) hypothesis, this concept is widely accepted among health and social scientists. However, it is unclear whether DOHaD-based ideas are reaching the general public and/or influencing behaviour. This study thus investigated whether and under what circumstances pregnant people in Canada are famil...
2 CitationsSource
#1Deborah M. Sloboda (McMaster University)H-Index: 36
#1Jessica G. Wallace (McMaster University)H-Index: 4
#2Christian J. Bellissimo (McMaster University)H-Index: 2
Last. Deborah M. SlobodaH-Index: 36
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We investigated whether diet-induced changes in the maternal intestinal microbiota were associated with changes in bacterial metabolites and their receptors, intestinal inflammation, and placental inflammation at mid-gestation (E14.5) in female mice fed a control (17% kcal fat, n = 7) or a high-fat diet (HFD 60% kcal fat, n = 9; ad libitum) before and during pregnancy. Maternal diet-induced obesity (mDIO) resulted in a reduction in maternal fecal short-chain fatty acid producing Lachnospiraceae,...
3 CitationsSource
#1Minglan Li (University of Auckland)H-Index: 13
#2Clare M. Reynolds (University of Auckland)H-Index: 24
Last. Mark H. Vickers (University of Auckland)H-Index: 38
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OBJECTIVE: Maternal obesity is associated with obesity and metabolic disorders in offspring. However, there remains a paucity of data on strategies to reverse the effects of maternal obesity on maternal and offspring health. With maternal undernutrition, taurine supplementation improves outcomes in offspring mediated in part via improved glucose-insulin homeostasis. The efficacy of taurine supplementation in the setting of maternal obesity on health and well-being of offspring is unknown. We exa...
1 CitationsSource
#1L. McKerracher (McMaster University)
#2Tina Moffat (McMaster University)H-Index: 11
Last. Deborah M. Sloboda (McMaster University)H-Index: 36
view all 5 authors...
Evidence supporting the Developmental Origins of Health and Disease (DOHaD) hypothesis indicates that improving early life environments can reduce non-communicable disease risks and improve health over the lifecourse. A widespread understanding of this evidence may help to reshape structures, guidelines and individual behaviors to better the developmental conditions for the next generations. Yet, few efforts have yet been made to translate the DOHaD concept beyond the research community. To unde...
#1Deborah M. Sloboda (McMaster University)H-Index: 36
: It is well established that early life environmental signals, including nutrition, set the stage for long-term health and disease risk - effects that span multiple generations. This relationship begins early, in the periconceptional period and extends into embryonic, fetal and early infant phases of life. Now known as the Developmental Origins of Health and Disease (DOHaD), this concept describes the adaptations that a developing organism makes in response to early life cues, resulting in adju...
5 CitationsSource