Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing
Abstract
Semi-autonomous functioning of mitochondria in eukaryotic cell necessitates coordination with nucleus. Several RNA species fine-tune mitochondrial processes by synchronizing with the nuclear program, however the involved components remain enigmatic. In this study, we identify a widely conserved dually localized protein Myg1, and establish its role as a 3′-5′ RNA exonuclease. We employ mouse melanoma cells, and knockout of the Myg1 ortholog in...
Paper Details
Title
Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing
Published Date
May 13, 2019
Journal
Volume
47
Issue
11
Pages
5852 - 5866
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