Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality
Abstract
The phagocyte NADPH oxidase is responsible for the neutrophil's great capacity to produce reactive oxygen species (ROS). The NADPH oxidase can be assembled in the plasma membrane, as well as in membranes of intracellular vesicles, giving neutrophils the ability to direct ROS production to distinct subcellular sites. Neutrophil ROS contribute to microbial killing, trigger formation of neutrophil extracellular traps and appear to partake in...
Paper Details
Title
Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality
Published Date
Jun 1, 2019
Journal
Volume
202
Issue
11
Pages
3127 - 3134
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