Abstract IA10: Deconstructing and reconstructing the ovarian cancer microenvironment

The tumor microenvironment (TME) is critical for cancer growth and spread. However, the relationships between molecular components of the TME and higher-order features, tissue stiffness, extent of disease, and cellularity are not known. Using clinical samples of metastatic high-grade serous ovarian cancer (HGSOC) that ranged from minimal to extensive disease, we have defined RNA and protein profiles that evolved with these higher-order features....