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Clinical Cancer Research
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21136
Papers 20983
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#1Stephen J. Bagley (UPenn: University of Pennsylvania)H-Index: 8
#2Seyed Ali Nabavizadeh (UPenn: University of Pennsylvania)H-Index: 9
Last.Erica L. Carpenter (UPenn: University of Pennsylvania)H-Index: 17
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Purpose: The clinical utility of plasma cell-free DNA (cfDNA) has not been assessed prospectively in patients with glioblastoma (GBM). We aimed to determine the prognostic impact of plasma cfDNA in GBM, as well as its role as a surrogate of tumor burden and substrate for next-generation sequencing (NGS). Experimental Design: We conducted a prospective cohort study of 42 patients with newly diagnosed GBM. Plasma cfDNA was quantified at baseline prior to initial tumor resection and longitudinally ...
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#1Mothaffar F. RimawiH-Index: 28
#2Polly A. NiravathH-Index: 8
Last.Ck OsborneH-Index: 19
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#1Shiyan Wang (CUHK: The Chinese University of Hong Kong)H-Index: 13
Purpose: Chromosomal instability (CIN) is a common phenomenon in colorectal cancer (CRC), but its role and underlying cause remain unknown. We have identified that mitotic regulator microtubule-associated protein 9 (MAP9) as a critical regulator of CIN in CRC. We thus studied the effect of MAP9 loss on CRC in Map9 knockout mice and in cell lines. Experimental Design: We generated colon epithelial-specific Map9 knockout mice and evaluated CRC development. Effect of Map9 knockout on CRC progressio...
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#1Carmine De AngelisH-Index: 13
#2Chandandeep NagiH-Index: 5
Last.Rachel SchiffH-Index: 59
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#1S. B. WedamH-Index: 6
Last.Julia A. BeaverH-Index: 11
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#1Jay Friedman (NIH: National Institutes of Health)H-Index: 14
#2Ellen C. Moore (NIH: National Institutes of Health)H-Index: 7
Last.Clint T. Allen (NIH: National Institutes of Health)H-Index: 12
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Purpose: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus-negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant disease relapse remains high. Perioperative immunotherapy may improve outcomes, but mechanistic data supporting the use of neoadjuvant or adjuvant treatment clinically is sparse. Experimental Design: T...
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#1Kristin C. HicksH-Index: 3
#2Karin M. KnudsonH-Index: 4
Last.Sofia GamieroH-Index: 17
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#1Stefano LuminariH-Index: 38
#2Benedetta DonatiH-Index: 12
Last.Alessia CiarrocchiH-Index: 19
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Purpose: Early response to ABVD, assessed with interim FDG-PET (iPET), is prognostic for classical Hodgkin9s Lymphoma (cHL) and supports the use of response adapted therapy. The aim of this study was to identify a gene-expression profile on diagnostic biopsy to predict iPET positivity (iPET+). Experimental Design: Consecutive untreated patients with stage I-IV cHL who underwent iPET after two cycles of ABVD were identified. Expression of 770 immune related genes was analyzed by digital expressio...
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