Recognition of 3′-end L1, Alu, processed pseudogenes, and mRNA stem-loops in the human genome using sequence-based and structure-based machine-learning models

The role of 3′-end stem-loops in retrotransposition was experimentally demonstrated for transposons of various species, where LINE-SINE retrotransposons share the same 3′-end sequences, containing a stem-loop. We have discovered that 62–68% of processed pseduogenes and mRNAs also have 3′-end stem-loops. We investigated the properties of 3′-end stem-loops of human L1s, Alus, processed pseudogenes and mRNAs that do not share the same sequences,...