EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
Abstract
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous recombination. Transcription of DSB-flanking sequences results in the production of damage-induced long non-coding RNAs (dilncRNAs) that engage in DNA-RNA hybrid formation. Depletion of EXOSC10,...
Paper Details
Title
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
Published Date
May 13, 2019
Journal
Volume
10
Issue
1
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