Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor
Abstract
Mxra8 is a receptor for multiple arthritogenic alphaviruses that cause debilitating acute and chronic musculoskeletal disease in humans. Herein, we present a 2.2 Å resolution X-ray crystal structure of Mxra8 and 4 to 5 Å resolution cryo-electron microscopy reconstructions of Mxra8 bound to chikungunya (CHIKV) virus-like particles and infectious virus. The Mxra8 ectodomain contains two strand-swapped Ig-like domains oriented in a unique...
Paper Details
Title
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor
Published Date
Jun 1, 2019
Journal
Volume
177
Issue
7
Pages
1725 - 1737.e16
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