The Effect of Prenatal Bone Lead Concentrations on Prepulse Inhibition: A Prospective Study of Mexican Children

Background: An important concern is the toxic legacy of prenatal lead exposure. During pregnancy, maternal skeletal bone lead from earlier exposures mobilizes and crosses placental barriers placing the developing fetus at risk for lead exposure and subsequent neurobehavioral deficits. Some of the neuronal circuits implicated in mechanisms of neurodevelopment can be probed with simple physiological behavioral paradigms, potentially serving as a...