Metabolic Effects of Bile Acids: Potential Role in Bariatric Surgery

Overall, metabolic benefits of altering intestinal BA availability include weight-dependent and weight-independent effects (Figure 2). Bile diversion increases circulating BAs and improves glucose tolerance without altering body weight. This improved glucose homeostasis is typically attributed to effects of weight loss when observed clinically, but our findings suggest the weight-independent effects of bariatric surgery on glucose metabolism are...