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Naji N. Abumrad
Vanderbilt University Medical Center
EndocrinologyInsulinDiabetes mellitusMedicineBiology
321Publications
50H-index
14kCitations
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Publications 320
Newest
#1Babak Banan (VUMC: Vanderbilt University Medical Center)H-Index: 11
#1Babak BananH-Index: 1
Last. Barbara Fingleton (Vandy: Vanderbilt University)H-Index: 39
view all 9 authors...
Current laboratory models of lymphatic metastasis generally require either genetically modified animals or are technically challenging. Herein, we have developed a robust protocol for the induction of intralymphatic metastasis in wild-type mice with reproducible outcomes. To determine an optimal injection quantity and timeline for tumorigenesis, C57Bl/6 mice were injected directly into the mesenteric lymph duct (MLD) with varying numbers of syngeneic murine colon cancer cells (MC38) or gastric c...
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#1Lisa M. Pitchford (Iowa State University)H-Index: 3
#2Patricia M. Driver (VUMC: Vanderbilt University Medical Center)
Last. Olivier Boutaud (Vandy: Vanderbilt University)H-Index: 31
view all 14 authors...
2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cognitive decline observed with Mild Cognitive Impairment or Alzheimer’s disease. This study evaluated the safety, tolerability, and pharmacokinetics of repeated oral doses of 2-HOBA acetate (500 or 750 mg) administered to healthy volunteers every eight hours ...
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#1Cyndya A. Shibao (Vandy: Vanderbilt University)H-Index: 24
#2Nada A. Abumrad (WashU: Washington University in St. Louis)H-Index: 61
Last. Nicholas C Breier (Vandy: Vanderbilt University)
view all 7 authors...
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#1Brian G. Engelhardt (VUMC: Vanderbilt University Medical Center)H-Index: 14
#2Ujjawal Savani (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. Naji N. Abumrad (VUMC: Vanderbilt University Medical Center)H-Index: 50
view all 10 authors...
Abstract New-onset post-transplant diabetes mellitus (PTDM) occurs frequently after allogeneic hematopoietic cell transplant (HCT). Although calcineurin inhibitors and corticosteroids are assumed to be the cause for hyperglycemia, patients developing PTDM have elevated fasting C-peptide levels before HCT and before immunosuppressive medications. To determine if PTDM results from established insulin resistance present before transplant, we performed oral glucose tolerance tests (OGTTs) and measur...
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#1Justin M. Gregory (Vandy: Vanderbilt University)H-Index: 7
#2T. Jordan Smith (Vandy: Vanderbilt University)H-Index: 1
Last. Daniel J. Moore (Vandy: Vanderbilt University)H-Index: 23
view all 14 authors...
Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic-euglycemic clamps in three participant groups (n = 10/group) with differing insulinemia and glycemia: healthy control subjects (euinsulinemia and euglycemia), glucokinase–maturity-onset diabetes of the young (GCK-MODY; euinsulinemia and hyperglycem...
3 CitationsSource
#1Julia P. DunnH-Index: 8
#2Naji N. AbumradH-Index: 50
Last. Robyn A. TamboliH-Index: 13
view all 5 authors...
: We aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potential (BPND). Reduced disposition index (DI), a β-cell function metric that can also be calculated by OMM, was shown to predict a negative reward behavior that occurs in states of lower endogenous DA. We hypothesized that reduced DI would occur with ...
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#1Ujjawal Savani (UM: University of Michigan)
#2Dae Kwang Jung (VUMC: Vanderbilt University Medical Center)H-Index: 2
Last. Brian G. Engelhardt (VUMC: Vanderbilt University Medical Center)H-Index: 14
view all 13 authors...
The mortality rate triples for the 50% of allogeneic hematopoietic cell transplant (HCT) recipients diagnosed new-onset post-transplant diabetes mellitus (PTDM). Calcineurin inhibitors and corticosteroids are assumed the cause for hyperglycemia, however patients developing PTDM have elevated fasting C-peptide levels before HCT. We tested the hypotheses that an oral glucose tolerance test (OGTT) would predict new-onset PTDM and that PTDM progresses from established insulin resistance present befo...
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#1Vance L. Albaugh (Vandy: Vanderbilt University)H-Index: 12
#2Babak Banan (Vandy: Vanderbilt University)H-Index: 1
Last. Charles R. Flynn (Vandy: Vanderbilt University)H-Index: 28
view all 10 authors...
Background & aims Bile diversion to the ileum (GB-IL) has strikingly similar metabolic and satiating effects to Roux-en-Y gastric bypass (RYGB) in rodent obesity models. The metabolic benefits of these procedures are thought to be mediated by increased bile acids, although parallel changes in body weight and other confounding variables limit this interpretation. Methods Global G protein–coupled bile acid receptor-1 null (Tgr5−/−) and intestinal-specific farnesoid X receptor null (FxrΔ/E) mice on...
14 CitationsSource
#1Lisa M. PitchfordH-Index: 3
#2John A. Rathmacher (Iowa State University)H-Index: 23
Last. Olivier Boutaud (Vandy: Vanderbilt University)H-Index: 31
view all 12 authors...
2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against the development of conditions associated with dicarbonyl electrophile formation, such as the cognitive decline associated with Mild Cognitive Impairment and Alzheimer’s disease. In this first-in-human study, the safety, to...
2 CitationsSource
#1Charles R. Flynn (VUMC: Vanderbilt University Medical Center)H-Index: 28
#2Vance L. Albaugh (VUMC: Vanderbilt University Medical Center)H-Index: 12
Last. Naji N. Abumrad (VUMC: Vanderbilt University Medical Center)H-Index: 50
view all 3 authors...
Bariatric surgery is the most effective and durable treatment for morbid obesity, with an unexplained yet beneficial side effect of restoring insulin sensitivity and improving glycemia, often before weight loss is observed. Among the many contributing mechanisms often cited, the altered handling of intestinal bile acids is of considerable therapeutic interest. Here, we review a growing body of literature examining the metabolic effects of bile acids ranging from their physical roles in dietary f...
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