Original paper
Analysis and minimization of cellular RNA editing by DNA adenine base editors
Abstract
Adenine base editors (ABEs) enable precise and efficient conversion of target A•T base pairs to G•C base pairs in genomic DNA with a minimum of by-products. While ABEs have been reported to exhibit minimal off-target DNA editing, off-target editing of cellular RNA by ABEs has not been examined in depth. Here, we demonstrate that a current ABE generates low but detectable levels of widespread adenosine-to-inosine editing in cellular RNAs. Using...
Paper Details
Title
Analysis and minimization of cellular RNA editing by DNA adenine base editors
Published Date
May 3, 2019
Journal
Volume
5
Issue
5
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Notes
History