Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane
Abstract
Mechanical and inflammatory signals in the fetal membrane play an important role in extracellular matrix (ECM) remodelling in order to dictate the timing of birth. We developed a mechanical model that mimics repetitive stretching of the amniotic membrane (AM) isolated from regions over the placenta (PAM) or cervix (CAM) and examined the effect of cyclic tensile strain (CTS) on mediators involved in mechanotransduction (Cx43, AKT), tissue...
Paper Details
Title
Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane
Published Date
Apr 30, 2019
Journal
Volume
9
Issue
1
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