Epigenomic profiling of DNA methylation for hepatocellular carcinoma diagnosis and prognosis prediction

Background and Aim DNA hypermethylation has emerged as a novel molecular biomarker for the diagnosis and prognosis prediction of many cancers. We aimed to identify clinically useful biomarkers regulated by DNA methylation in hepatocellular carcinoma (HCC). Methods Genome‐wide methylation analysis in HCCs and paired noncancerous tissues was performed using an Illumina Infinium HumanMethylation 450K BeadChip array. Methylation‐specific polymerase...