Original paper
Buprenorphine Markedly Elevates a Panel of Surrogate Markers in a Murine Model of Sepsis
Abstract
Sepsis can be simulated in animals by perforating the cecum via a surgical procedure termed "cecal ligation and puncture" (CLP), which induces similar inflammatory responses as observed during the clinical course of human sepsis. In addition to anesthetic agents, many Institutional Animal Care and Use Committees often recommend the use of additional analgesic agents (such as opioid) to further augment the initial anesthetic effects. However,...
Paper Details
Title
Buprenorphine Markedly Elevates a Panel of Surrogate Markers in a Murine Model of Sepsis
Published Date
Nov 1, 2019
Journal
Volume
52
Issue
5
Pages
550 - 553
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Notes
History