Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Abstract
Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING balances activation of IRF3- and NF-κB-dependent transcription and discover that acquisition of discrete signaling modules in the vertebrate STING C-terminal tail (CTT) shapes downstream immunity. As a defining example, we identify a motif appended...
Paper Details
Title
Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
Published Date
Apr 1, 2019
Journal
Volume
27
Issue
4
Pages
1165 - 1175.e5
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