Mammalian haploid stem cells: establishment, engineering and applications
Abstract
Haploid embryonic stem cells (haESCs) contain only one set of genomes inherited from the sperm or egg and are termed AG- or PG-haESCs, respectively. Mammalian haESCs show genome-wide hypomethylation and dysregulated imprinting, whereas they can sustain genome integrity during derivation and long-term propagation. In addition, haESCs exhibit similar pluripotency to traditional diploid ESCs but are unique because they function as gametes and have...
Paper Details
Title
Mammalian haploid stem cells: establishment, engineering and applications
Published Date
Mar 19, 2019
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