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Cellular and Molecular Life Sciences
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#1Bethany Mason (University of Cambridge)H-Index: 3
#2Susanne Flach (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Heike Laman (University of Cambridge)H-Index: 18
view all 9 authors...
In cancer, many genes are mutated by genome rearrangement, but our understanding of the functional consequences of this remains rudimentary. Here we report the F-box protein encoded by FBXL17 is disrupted in the region of the gene that encodes its substrate-binding leucine rich repeat (LRR) domain. Truncating Fbxl17 LRRs impaired its association with the other SCF holoenzyme subunits Skp1, Cul1 and Rbx1, and decreased ubiquitination activity. Loss of the LRRs also differentially affected Fbxl17 ...
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#1Rosario Morrugares (UCO: University of Córdoba (Spain))H-Index: 2
#2Alejandro Correa-Sáez (UCO: University of Córdoba (Spain))H-Index: 1
Last. Marco A. Calzado (UCO: University of Córdoba (Spain))H-Index: 25
view all 7 authors...
NOTCH proteins constitute a receptor family with a widely conserved role in cell cycle, growing and development regulation. NOTCH1, the best characterised member of this family, regulates the expression of key genes in cell growth and angiogenesis, playing an essential role in cancer development. These observations provide a relevant rationale to propose the inhibition of the intracellular domain of NOTCH1 (Notch1-IC) as a strategy for treating various types of cancer. Notch1-IC stability is mai...
1 CitationsSource
#1Xin Li (Fourth Military Medical University)H-Index: 8
#2Xiuquan Wu (Fourth Military Medical University)
Last. Lize Xiong (Fourth Military Medical University)H-Index: 39
view all 4 authors...
In recent years, the roles of astrocytes of the central nervous system in brain function and neurological disease have drawn increasing attention. As a member of the N-myc downstream-regulated gene (NDRG) family, NDRG2 is principally expressed in astrocytes of the central nervous system. NDRG2, which is involved in cell proliferation and differentiation, is commonly regarded as a tumor suppressor. In astrocytes, NDRG2 affects the regulation of apoptosis, astrogliosis, blood–brain barrier integri...
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#1James W. Connell (University of Cambridge)H-Index: 11
#2Rachel Allison (University of Cambridge)H-Index: 9
Last. Evan Reid (University of Cambridge)H-Index: 35
view all 6 authors...
Mutations in the gene encoding the microtubule severing ATPase spastin are the most frequent cause of hereditary spastic paraplegia, a genetic condition characterised by length-dependent axonal degeneration. Here, we show that HeLa cells lacking spastin and embryonic fibroblasts from a spastin knock-in mouse model become highly polarised and develop cellular protrusions. In HeLa cells, this phenotype was rescued by wild-type spastin, but not by forms unable to sever microtubules or interact with...
2 CitationsSource
#1Andrey Ivanov (HU: Howard University)H-Index: 7
#2Palaniappan Ramanathan (UTMB: University of Texas Medical Branch)H-Index: 1
Last. Sergei Nekhai (HU: Howard University)H-Index: 28
view all 11 authors...
Ebola virus (EBOV) causes severe human disease with a high case fatality rate. The balance of evidence implies that the virus circulates in bats. The molecular basis for host–viral interactions, including the role for phosphorylation during infections, is largely undescribed. To address this, and to better understand the biology of EBOV, the phosphorylation of EBOV proteins was analyzed in virions purified from infected monkey Vero-E6 cells and bat EpoNi/22.1 cells using high-resolution mass spe...
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#1Daniel Gonzalez (University of Burgundy)H-Index: 8
#1Daniel Gonzalez (University of Burgundy)H-Index: 2
Last. Loïc Briand (University of Burgundy)H-Index: 9
view all 10 authors...
Odorant-binding proteins (OBPs) are small soluble proteins that are thought to transport hydrophobic odorants across the aqueous sensillar lymph to olfactory receptors. A recent study revealed that OBP28a, one of the most abundant Drosophila OBPs, is not required for odorant transport, but acts in buffering rapid odour variation in the odorant environment. To further unravel and decipher its functional role, we expressed recombinant OBP28a and characterized its binding specificity. Using a fluor...
3 CitationsSource
#1Hwan Tae Park (Dong-a University)H-Index: 20
#2Young Hee Kim (Dong-a University)H-Index: 3
Last. Jong Kuk Kim (Dong-a University)H-Index: 17
view all 4 authors...
In inflammatory peripheral demyelinating disorders, demyelination represents segmental demyelination in which the myelin sheath of a myelinating Schwann cell (SC) is completely removed by macrophages or a partial myelin degeneration in the paranode occurring due to autoantibodies attacking the node/paranode. For the segmental demyelination from living myelin-forming SCs, macrophages infiltrate within the endoneurium and insinuate between myelin lamellae and the cytoplasm of SCs, and the myelin i...
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#1Li-Qun Lu (CSU: Central South University)
#2Jing Tian (CSU: Central South University)H-Index: 2
Last. Jun Peng (CSU: Central South University)H-Index: 23
view all 4 authors...
Apoptosis, necrosis and autophagy-dependent cell death are the three major types of cell death. Traditionally, necrosis is thought as a passive and unregulated form of cell death. However, certain necrosis can also occur in a highly regulated manner, referring to regulated necrosis. Depending on the signaling pathways, regulated necrosis can be further classified as necroptosis, pyroptosis, ferroptosis, parthanatos and CypD-mediated necrosis. Numerous studies have reported that regulated necrosi...
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#1Giulia Murtas (University of Insubria)H-Index: 4
#2Giorgia Letizia Marcone (University of Insubria)H-Index: 14
Last. Loredano Pollegioni (University of Insubria)H-Index: 44
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L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and methylenetetrahydrofolate. Moreover, L-serine is the precursor of two relevant coagonists of NMDA receptors: glycine (through the enzyme serine hydroxymethyltransferase), which preferentially acts on extrasynaptic receptors and D-serine (through the enzyme serine racemase), dominant at synaptic receptors. The cytosolic "phosp...
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#1Madeline Nieves-Cintrón (UC Davis: University of California, Davis)H-Index: 17
#2Víctor A. Flores-Tamez (UC Davis: University of California, Davis)
Last. Manuel F. Navedo (UC Davis: University of California, Davis)H-Index: 25
view all 5 authors...
Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality in diabetes is hyperglycemia, which contributes to the pathogenesis of cardiovascular complications. These cardiovascular complications are, at least in part, related to hyperglycemia-induced molecular and cellular changes in the cells making up blood vessels. Whereas the mechanisms mediating endothelial dysfunction durin...
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