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The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials

Published on May 1, 2019in Diabetes and Metabolic Syndrome: Clinical Research and Reviews
· DOI :10.1016/j.dsx.2019.04.043
Saba Loloei1
Estimated H-index: 1
(Tehran University of Medical Sciences),
Mahdi Sepidarkish6
Estimated H-index: 6
(Babol University of Medical Sciences)
+ 4 AuthorsHamed Pouraram5
Estimated H-index: 5
(Tehran University of Medical Sciences)
Abstract
Abstract Background Epidemiological evidence suggests that melatonin has some effects on the serum lipid. However, these results are controversial. The aim of this systematic review and meta-analysis is to examine the effect of melatonin supplement on dyslipidemia and anthropometric indices. Methods We searched electronic databases including Medline, Embase, Scopus, Web of Science and Cochrane Library up to Des 2018 without any language restriction. To compare the effects of melatonin with placebo, differences in standardized means difference (SMD) with 95% confidence intervals (95% CI) were pooled using random effects model. Results Twelve trials including 641 participants included in meta-analysis finally. The dose of melatonin was reported at 0.8–30 mg. Comparing with the control group, melatonin may improve low density lipoprotein cholesterol (LDL-C) (−0.31 mmol/L, 95% CI (−0.61, 0.01), P = 0.049, I2 = 42%) and triglyceride (TG) level (SMD = −0.45 mmol/L; 95% CI, −0.77, −0.13, P = 0.006, I2 = 47%). No significant effect of melatonin on high density lipoprotein cholesterol (HDL-C) and anthropometric indices was found. Conclusions The results of our systematic review and Meta-analyzes showed that supplementation of melatonin could be effective in improving lipid parameters and should be considered in the prevention of cardiovascular disease, although the effect of this supplement on anthropometric indices needs further investigation.
  • References (39)
  • Citations (2)
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References39
Newest
#1Fariba Raygan (KAUMS: Kashan University of Medical Sciences)H-Index: 9
#2Vahidreza Ostadmohammadi (KAUMS: Kashan University of Medical Sciences)H-Index: 7
Last. Zatollah Asemi (KAUMS: Kashan University of Medical Sciences)H-Index: 29
view all 5 authors...
Summary Background & aims Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administration on metabolic status in diabetic patients with CHD. Methods This randomized, double-blind, placebo-controlled trial was conducted and involved 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to receive either 1...
20 CitationsSource
#1Mohsen Mohammadi-Sartang (Shiraz University of Medical Sciences)H-Index: 5
#2Mohammad GhorbaniH-Index: 5
Last. Zohreh Mazloom (Shiraz University of Medical Sciences)H-Index: 9
view all 3 authors...
Summary Background & aims Melatonin supplementation may be associated with blood lipids improvement; however, the current evidence from randomized controlled trials (RCTs) is inconsistent. The present study aimed to systematically review and analyze RCTs assessing the effects of melatonin supplementation on blood lipids. Methods A comprehensive literature search in several database was performed up to January 2017. Quantitative data synthesis was performed using a fixed or random-effects model, ...
12 CitationsSource
Background: Some trials on animals and human claim that melatonin can influence body weight. So we conducted a systematic review of controlled trials of melatonin effects on weight of human subjects. Methods: First we performed a systematic and comprehensive search in June 2015 on MEDLINE/PubMed, Scopus, Google scholar, hand searching in key journals, the list of references of selected articles and gray literature. Results: We included 7 clinical trials with a total of 244 patients. All studies ...
7 CitationsSource
#1Russel J. Reiter (University of Texas Health Science Center at San Antonio)H-Index: 148
#2Juan C. Mayo (University of Texas Health Science Center at San Antonio)H-Index: 42
Last. Lilian Qin (University of Texas Health Science Center at San Antonio)H-Index: 1
view all 6 authors...
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and reactive nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing the activity of pro-oxidant enzymes. In addition to these well-described actions, melatonin also reportedly chelates transition metals, which are involved in the Fenton/Haber–Weiss reactions; in doing...
350 CitationsSource
#1Zhanqi Wang (Peking Union Medical College Hospital)H-Index: 4
#2Leng Ni (Peking Union Medical College Hospital)H-Index: 8
Last. Changwei Liu (Peking Union Medical College Hospital)H-Index: 11
view all 7 authors...
Smoking is one of the most harmful lifestyles in the world. Very few studies have investigated the effects of melatonin in smoke-induced vascular injury. This study was designed to investigate whether melatonin could protect rats and humans from smoke-induced vascular injury. 32 male rats and a double-blind randomized controlled trial (RCT) containing 63 participants formed the subjects of this study. In rats, 10 mg/kg of melatonin was intraperitoneally injected. Blood samples and abdominal arte...
22 CitationsSource
#1Cezary Chojnacki (Medical University of Łódź)H-Index: 11
#2Walecka-Kapica E (Medical University of Łódź)H-Index: 6
Last. Jan Chojnacki (Medical University of Łódź)H-Index: 13
view all 6 authors...
Frequent mood and sleep disorders and increased appetite leading to obesity are observed in postmenopausal women. Due to the limitations of hormone replacement therapy the researchers look for other treatment regimes. The aim of the study was to evaluate the efficacy of fluoxetine and melatonin in the treatment of these disorders. The study included 64 overweight postmenopausal women, aged 54 - 65 years, with increased appetite. They were randomly assigned in 2 groups. In group I (n = 30) fluoxe...
16 Citations
#1Hang Sun (Tongji University)H-Index: 4
#2Fang-fang Huang (Tongji University)H-Index: 1
Last. Shen Qu (Tongji University)H-Index: 20
view all 3 authors...
Melatonin (N-acetyl-5-methoxytryptamine, MLT) is a neuroendocrine hormone, which is primarily synthesized by the pineal gland in vertebrates. Melatonin is a remarkable molecule with diverse biological and physiological actions and is involved in the regulation of various important functions such as circadian rhythm, energy metabolism, the reproductive system, the cardiovascular system, and the neuropsychiatric system. It also plays a role in disease by having anti-neoplastic and anti-osteoarthri...
17 CitationsSource
#1David Moher (Ottawa Hospital Research Institute)H-Index: 100
#2Larissa Shamseer (Ottawa Hospital Research Institute)H-Index: 24
Last. Lesley A. Stewart (Ebor: University of York)H-Index: 45
view all 8 authors...
Systematic reviews should build on a protocol that describes the rationale, hypothesis, and planned methods of the review; few reviews report whether a protocol exists. Detailed, well-described protocols can facilitate the understanding and appraisal of the review methods, as well as the detection of modifications to methods and selective reporting in completed reviews. We describe the development of a reporting guideline, the Preferred Reporting Items for Systematic reviews and Meta-Analyses fo...
3,553 CitationsSource
#1Abhinav Goyal (Emory University)H-Index: 15
#2Paul Terry (UT: University of Tennessee)H-Index: 20
Last. Michael Kutner (Emory University)H-Index: 9
view all 7 authors...
Background Supplemental melatonin may ameliorate metabolic syndrome (MetS) components, but data from placebo-controlled trials are lacking.
28 CitationsSource
#1Miguel Navarro-Alarcón (UGR: University of Granada)H-Index: 23
#2Francisco Javier Ruiz-Ojeda (UGR: University of Granada)H-Index: 10
Last. Ahmad Agil (UGR: University of Granada)H-Index: 20
view all 7 authors...
Human life expectancy has increased over the past 50 years due to scientific and medical advances and higher food availability. However, overweight and obesity affect more than 50% of adults and 15% of infants and adolescents. There has also been a marked increase in the prevalence of metabolic syndrome in recent decades, which has been associated with a reduction in nocturnal pineal production of melatonin with aging and an increased risk of coronary diseases, type 2 diabetes mellitus (T2DM) an...
31 CitationsSource
Cited By2
Newest
#1Baitao Ma (Peking Union Medical College Hospital)H-Index: 1
#2Yunfei Chen (Peking Union Medical College)
Last. Changwei Liu (Peking Union Medical College Hospital)H-Index: 11
view all 9 authors...
BACKGROUND: Cigarette smoke (CS) exposure impairs serum lipid profiles and the function of vascular endothelial cells, which accelerates the atherosclerosis. However, the precise mechanism and effect on the expression of low-density lipoprotein receptor (LDLR) in the liver by CS exposure is still unclear. METHODS: In this study, adult male C57BL/6 J mice were divided into three groups, with one group being exposed to CS for 6 weeks. HepG2 cells were treated with CS extract at concentrations of 1...
Source
#1Anahita MansooriH-Index: 4
#2Zahra Salimi (Ahvaz Jundishapur University of Medical Sciences)
Last. Maryam AsadiH-Index: 1
view all 6 authors...
Abstract Several randomized clinical trials (RCTs) evaluated the effect of melatonin supplementation on liver enzymes in patients with non-alcoholic fatty liver disease (NAFLD) and reported conflicting results. To meet these discrepancies, a meta-analysis was conducted to evaluate the effect of melatonin on liver indices in patients with NAFLD. To collect the required data, a thorough search was conducted through Web of science, Pubmed, Cochrane database, Embase, Google Scholar, ProQuest, and Sco...
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Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose tissue that results from the exacerbated consumption of calories associated with low energy expenditure. Fat accumulation in both adipose tissue and other organs contributes to a systemic inflammation leading to the development of metabolic disorders such as type 2 diabetes, hypertension, and dyslipidemia. Melatonin is a potent antioxidant and improves inflammatory processes and energy metabolism. Using ...
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