Original paper
Inhibition of GIP signaling extends lifespan without caloric restriction
Volume: 513, Issue: 4, Pages: 974 - 982
Published: Jun 1, 2019
Abstract
Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-dependent augmentation of insulin secretion and uptake of nutrients into the adipose tissue. Gipr-/- and Gipr+/+ mice were used for lifespan analysis,...
Paper Details
Title
Inhibition of GIP signaling extends lifespan without caloric restriction
Published Date
Jun 1, 2019
Volume
513
Issue
4
Pages
974 - 982
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