Personalized Detection of Circulating Tumor DNA Antedates Breast Cancer Metastatic Recurrence

Up to 30% of patients with breast cancer relapse after primary treatment. There are no sensitive and reliable tests to monitor these patients and detect distant metastases before overt recurrence. Here, we demonstrate the use of personalized circulating tumor DNA (ctDNA) profiling for detection of recurrence in breast cancer.Forty-nine primary patients with breast cancer were recruited following surgery and adjuvant therapy. Plasma samples (n =...