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Molecular Insight and Mode of Inhibition of α‐Glucosidase and α‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.

Published on May 9, 2019in Chemistry & Biodiversity1.449
· DOI :10.1002/cbdv.201900032
Kong Yong Loo1
Estimated H-index: 1
(UM: University of Malaya),
Kok Hoong Leong10
Estimated H-index: 10
(UM: University of Malaya)
+ 2 AuthorsKhalijah Awang29
Estimated H-index: 29
(UM: University of Malaya)
Abstract
  • References (22)
  • Citations (0)
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Abstract A new acylphenol, malabaricone E ( 1 ) together with the known malabaricones A-C ( 2 – 4 ), maingayones A and B ( 5 and 6 ) and maingayic acid B ( 7 ) were isolated from the ethyl acetate extract of the fruits of Myristica cinnamomea King. Their structures were determined by 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 3 (1.84 ± 0.19 and 1.76 ± 0.21 μM, respectively) and 4 (1.94 ± 0.27 and 2.80 ± 0.49 μM, respectively) were identified as dual inhibitors, with almost equa...
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Abstract A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC 50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC 50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver–Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report o...
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Abstract Oxadiazoles and thiadiazoles 1 – 37 were synthesized and evaluated for the first time for their α-glucosidase inhibitory activities. As a result, fifteen of them 1 , 4 , 5 , 7 , 8 , 13 , 17 , 23 , 25 , 30 , 32 , 33 , 35 , 36 and 37 were identified as potent inhibitors of the enzyme. Kinetic studies of the most active compounds (oxadiazoles 1 , 23 and 25 , and thiadiazoles 35 and 37 ) were carried out to determine their mode of inhibition and dissociation constants K i . The most potent ...
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The rhizomes of Alpinia pahangensis Ridley yielded a new bis-labdanic diterpene for which the name pahangensin A (1) was proposed along with a new labdane diterpene, pahangensin B (2). Their structures were elucidated by spectroscopic methods including, 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Pahangensin A (1) was found to be an antibacterial agent against Staphylococcus aureus, Bacillus cereus and Bacillus subtilis with MIC values less than 100 lg/mL, respectively. Pahangensin B (2) ...
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