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#1Songze Ke (Zhejiang University of Technology)H-Index: 1
#2Bin Wei (Zhejiang University of Technology)H-Index: 2
Last. Hong Wang (Zhejiang University of Technology)H-Index: 6
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Two sulfated fucoidan fractions (Lj3 and Lj5) were extracted from Saccharina japonica and then subjected to acid hydrolysis to obtain Lj3h and Lj5h. Lj3h and Lj5h were characterized using IR, methylation analysis, and mass spectrometry. It was found that Lj3h and Lj5h were homogeneous low molecular weight fucoidans. Specifically, Lj3h was composed of the main chain of 1,3-linked alpha-L-fucopyranose residues with sulfate at C-2 and/or C-4 and three different monosaccharides (galactose, glucose, ...
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#1Hwan Myung Lee (Hoseo University)H-Index: 15
#2Do Yoon Kim (Hoseo University)H-Index: 2
Last. Yali Li (Hoseo University)
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Zea mays L. (ZM) has anticancer and anti-inflammatory activites, but its biological activities such as skin regeneration and wound healing in human skin have not reported. In the present study, we tested the effects of ZM flower (ZMF) absolute on proliferation and migration of human keratinocytes (HaCaTs) and identified its components by using gas chromatography/mass spectrometry (GC/MS) analysis. GC/MS analysis revealed that the ZMF absolute contained 13 constituents, and it increased HaCaT pro...
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#1Qingqing Han (Yantai University)
#2Lijuan Han (Qinghai University)
Last. Gang Li (Yantai University)H-Index: 7
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20( S )-protopanaxadiol ginsenosides Rg3, Rh2 and PPD have been demonstrated for their anticancer activity. However, the underlying mechanism of their anti-tumor activity remains unclear. In the present study, we investigated the role of these three ginsenosides on cell proliferation and death of human gastric cancer cells (HGC-27 cells). The sulforhodamine B (SRB) assay, western blot analysis, fluorescence microscopy, confocal microscopy, high performance liquid chromatography (HPLC) analysis, ...
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#1Nan WangH-Index: 1
#2Yuan DongH-Index: 1
Last. Cheng-Bin Cui (Academy of Military Medical Sciences)H-Index: 1
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Penicimutanin C (1), a new alkaloidal compound, was isolated from the neomycin-resistant mutant strain 3-f-31 of the marine-derived fungus, Penicillium purpurogenum G59, together with four known compounds 2-5. The structure of penicimutanin C (1), including the absolute configuration, was determined by spectroscopic and chemical methods. The absolute configuration of penicimutanin A (2) was also re-confirmed by Marfey's and chiral HPLC analysis of the hydrolyzed products. Penicimutanins C (1) an...
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#1Motohiko Ukiya (College of Science and Technology)H-Index: 29
#2Daisuke Sato (YU: Yamagata University)H-Index: 6
Last. Atsuyoshi Nishina (College of Science and Technology)H-Index: 14
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In this study, melanogenesis inhibition in B16 cells by eight compounds, namely, tokorogenin, tokoronin, yononin, gracillin, proto-yonogenin, proto-tokoronin, proto-yononin, and proto-gracillin, isolated from Dioscorea tokoro Makino ex Miyabe were evaluated. The results of the cytotoxicity and alpha-MSH-induced melanogenesis inhibition effects of the eight compounds revealed that tokoronin was the most effective in terms of low-cytotoxicity and melanogenesis inhibition. Tokoronin downregulated a...
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#1Ruo-Lan Wang (SDU: Shandong University)
#2Yang Gao (SDU: Shandong University)
Last. Xiang Xing (SDU: Shandong University)
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The essential oils (EOs) from leaves, stems, and whole plant of Piper boehmeriifolium were analyzed using GC/FID and GC/MS. The main constituents of P. boehmeriifolium EOs were beta -caryophyllene, caryophyllene oxide, beta -elemene, spathulenol, germacrene D, beta -selinene, and neointermedeol. The antioxidant potential of the EOs were determined using DPPH * , ABTS *+ and FRAP assays. In ABTS *+ assay, the leaf oil exhibited a remarkable activity with an IC 50 value of 7.36 mug/mL almost simil...
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#1Hanaa MoussaH-Index: 2
#2Elías Quezada (University of Santiago de Compostela)H-Index: 10
Last. José Gil-Longo (University of Santiago de Compostela)H-Index: 9
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Carpodesmia tamariscifolia is a brown alga rich in (poly)phenols with important cytotoxic and antioxidant effects. However, the relationship between its chemical composition and its effects is unknown. The aim of this study is to identify the potential compounds and mechanisms responsible for its main effects. The alga was extracted consecutively with hexane, dichloromethane and methanol and further fractionated using Sephadex LH-20 and silica gel columns when appropriate. The fractions were sub...
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#1Meliha Burcu Gürdere (Gaziosmanpaşa University)H-Index: 5
#2Ali Aydin (Bozok Universitesi)
Last. Mustafa Ceylan (Gaziosmanpaşa University)H-Index: 14
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Novel enamine derivatives (7a-o) were synthesized from the reaction of lactone (6) and chalcones (3a-o) and their antiproliferative and cell cytotoxicity activities against six cancer cell lines (e.g., HeLa, HT29, A549, MCF7, PC3 and Hep3B) and one normal cell line (e.g., FL) were investigated along with their mode of interactions with CT-DNA. Most of the enamine derivatives (7a-o) with 86-168 microM IC50 values demonstrated much stronger antiproliferative activity than the starting molecules (3...
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#1Olena Kholodniak (Zaporizhia State Medical University)H-Index: 1
#2M. S. KazuninH-Index: 1
Last. Karl G. SteffensH-Index: 1
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A synthesis method of novel N -cycloalkylcarbonyl developed. It consists of sequential addition of equimolecular amounts of ammonium isothiocyanate and substituted anilines to cycloalkylcarbonyl chlorides. The identity and purity of products were confirmed by LC-MS spectra, their structure by elemental analysis, IR and 1 H NMR spectra. Preliminary antimicrobial screening for standard microorganisms and molecular docking allowed to select several structures for antifungal and genetic toxicity stu...
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#1Heinz Heimgartner (UZH: University of Zurich)H-Index: 34
#2Christoph Bucher (Novartis)H-Index: 3
Last. Anthony Linden (UZH: University of Zurich)H-Index: 40
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A series of tetrapeptide amides containing two aminoisobutyric acids (Aib) and two a-methylphenylalanine ((aMe)Phe) units were prepared via the 'azirine/oxazolone method'. New 2-benzyl-2-methyl-2 H -azirine-3-amines have been used for the selective introduction of ( S )- and ( R )-(aMe)Phe, respectively. The solid-state conformations of five tetrapeptide amides were determined by X-ray crystallography. In all cases, two b-turns stabilize 3 10 -helical conformations and it was confirmed that, in ...
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Organic chemistry
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Essential oil
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