Effects of Water Loading on Observed and Predicted Plasma Sodium, and Fluid and Urine Cation Excretion in Healthy Individuals

Rationale & Objective The discovery of sodium storage without concurrent water retention suggests the presence of an additional compartment for sodium distribution in the body. The osmoregulatory role of this compartment under hypotonic conditions is not known. Study Design Experimental interventional study. Setting & Participants Single-center study of 12 apparently healthy men. Intervention To investigate whether sodium can be released from...