Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy
Abstract
Diabetic cardiomyopathy is one of the main causes of heart failure and death in patients with diabetes mellitus. Reactive oxygen species produced excessively in diabetes mellitus cause necrosis, apoptosis, ferroptosis, inflammation, and fibrosis of the myocardium as well as impair the cardiac structure and function. It is increasingly clear that oxidative stress is a principal cause of diabetic cardiomyopathy. The transcription factor nuclear...
Paper Details
Title
Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy
Published Date
May 30, 2019
Journal
Volume
60
Issue
3
Pages
512 - 520
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