659 Oxazolone-induced atopic dermatitis murine model shifts from a Th2-dominant response in early challenge into a Th1-elevated response after repetition

Oxazolone (Ox)-induced atopic dermatitis (AD) murine model has been considered to have immunological and biochemical changes similar to those of AD including Th2 immune response. However, alteration in Th1/Th2 balance during repeated applications was poorly studied. We investigated the serial change in the Th1/Th2 profile exhibited in T-cell subsets (either Th1 and Th2 lymphocytes) and the Th1/ Th2-related cytokines during the repeated challenge...