Peripheral and central sensitization and neuropathic pain are present in both osteoarthritis and rheumatoid arthritis

Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) are among the most common chronic painful rheumatic diseases. Whereas pain sensitization in OA is widely understood to be a source of OA pain, it is unclear whether this is pathophysiologically related to the OA process or is a feature of articular disease in general. In contrast to OA, RA is a systemic inflammatory condition that causes chronic inflammation-based pain. We compared...