Ketamine-(Dex)Medetomidine, Hyperglycemia, Glycocalyx, and Vascular Permeability

To the Editor Guerci et al1 used an in vivo rat model of hemorrhagic shock to investigate the clinically relevant question whether breakdown of the glycocalyx results in increased vascular permeability. They found that the induction of hemorrhagic shock increased levels of glycocalyx breakdown products but did not change vascular permeability, as indicated by a similar retention ratio of 0.8 for infused Alexa 70 kDa albumin (Figure 3B). The...