Coert J. Zuurbier
University of Amsterdam
Publications 105
#1Laween Uthman (UvA: University of Amsterdam)H-Index: 3
#2Rianne Nederlof (HHU: University of Düsseldorf)H-Index: 3
Last.Coert J. Zuurbier (UvA: University of Amsterdam)H-Index: 27
view all 10 authors...
#1Coert J. Zuurbier (UvA: University of Amsterdam)H-Index: 27
#2Antonio AbbateH-Index: 54
Last.Sean M. Davidson (UCL: University College London)H-Index: 48
view all 11 authors...
#1Mathijs R. WirtzH-Index: 3
#2Jordy JurgensH-Index: 1
Last.Nicole P. JuffermansH-Index: 35
view all 8 authors...
BACKGROUND: Transfusion is associated with organ failure and nosocomial infection in trauma patients, which may be mediated by soluble bioactive substances in blood products, including extracellular vesicles (EVs). We hypothesize that removing EVs, by washing or filtering of blood products, reduces organ failure and improves host immune response. MATERIALS AND METHODS: Blood products were prepared from syngeneic rat blood. EVs were removed from RBCs and platelets by washing. Plasma was filtered ...
#1Kirsten F. SmitH-Index: 5
#2Moritz KonkelH-Index: 1
Last.Nina C. WeberH-Index: 25
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Caveolins are involved in anaesthetic-induced cardioprotection. Actin filaments are located in close connection to Caveolins in the plasma membrane. We hypothesised that helium might affect the cytoskeleton and induce secretion of Caveolin. HCAEC, HUVEC and Cav-1 siRNA transfected HUVEC were exposed for 20 minutes to either helium (5% CO2, 25% O2, 70% He) or control gas (5% CO2, 25% O2, 70% N2). Cells and supernatants were collected for infrared Western blot analysis, immunofluorescence staining...
#1Laween Uthman (UvA: University of Amsterdam)H-Index: 3
#2Antonius Baartscheer (UvA: University of Amsterdam)H-Index: 23
Last.Coert J. Zuurbier (UvA: University of Amsterdam)H-Index: 27
view all 9 authors...
Sodium glucose cotransporter 2 inhibitors (SGLT2i) are the first antidiabetic compounds that effectively reduce heart failure hospitalization and cardiovascular death in type 2 diabetics. SGLT2i were designed to decrease serum glucose levels by inhibiting SGLT2 in the kidney and to induce glycosuria. Direct off-target cardiac actions of SGLT2i have recently been documented. Here, we review the effects of SGLT2i on the various cardiac cell types and on cardiac function, and discuss how these may ...
#1Michel van WeeghelH-Index: 8
#2Desiree Abdurrachim (TU/e: Eindhoven University of Technology)H-Index: 8
Last.Sander M. Houten (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 47
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Aims Mitochondrial fatty acid oxidation (FAO) is an important energy provider for cardiac work and changes in cardiac substrate preference are associated with different heart diseases. Carnitine palmitoyltransferase 1B (CPT1B) is thought to perform the rate limiting enzyme step in FAO and is inhibited by malonyl-CoA. The role of CPT1B in cardiac metabolism has been addressed by inhibiting or decreasing CPT1B protein or after modulation of tissue malonyl-CoA metabolism. We assessed the role of CP...