Feasibility of entirely subcutaneous ICD™ systems in patients with coronary artery disease

Published on Nov 1, 2019in Clinical Research in Cardiology4.91
· DOI :10.1007/s00392-019-01455-5
Kevin Willy2
Estimated H-index: 2
Markus Bettin5
Estimated H-index: 5
+ 7 AuthorsGerrit Frommeyer18
Estimated H-index: 18
Background The subcutaneous ICD (S-ICD™) is an important advance in device therapy for the prevention of sudden cardiac death (SCD). Although current guidelines recommend S-ICD™ use, long-term data are still limited, especially in subgroups. Among several cardiac diseases that prone to SCD, coronary artery disease (CAD) carries several peculiarities that may hamper S-ICD™ therapy in this cohort. CAD can lead to an ischemic cardiomyopathy (ICM) with a reduced left-ventricular ejection fraction (LVEF) and bundle branch blocks, which can be difficult for ICD sensing and discrimination of arrhythmia. CAD is mainly driven by risk factors such as diabetes mellitus, which put these patients at an elevated risk for infectious complications of cardiac devices. Furthermore, in ICM myocardial scars are frequent and are a potential substrate for ventricular tachycardia, which may be accessible for antitachycardia pacing. At the moment, it remains unclear if there is a value of S-ICD™ therapy in this subgroup. Therefore, this study analysed patients with CAD.
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#1Tom F. Brouwer (UvA: University of Amsterdam)H-Index: 13
#2Reinoud E. Knops (UvA: University of Amsterdam)H-Index: 24
Last.Jeff S. Healey (Population Health Research Institute)H-Index: 62
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#1Bart A. Mulder (UG: University of Groningen)H-Index: 7
#2Alexander H. Maass (UG: University of Groningen)H-Index: 20
Last.Yuri Blaauw (UG: University of Groningen)H-Index: 13
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#1Reinoud E. Knops (AMC: Academic Medical Center)H-Index: 4
#2Tom F. Brouwer (AMC: Academic Medical Center)H-Index: 13
Last.Martin C. Burke Do (U of C: University of Chicago)H-Index: 23
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