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Clinical Research in Cardiology
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4.91
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2110
Papers 2155
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Background The subcutaneous ICD (S-ICD™) is an important advance in device therapy for the prevention of sudden cardiac death (SCD). Although current guidelines recommend S-ICD™ use, long-term data are still limited, especially in subgroups. Among several cardiac diseases that prone to SCD, coronary artery disease (CAD) carries several peculiarities that may hamper S-ICD™ therapy in this cohort. CAD can lead to an ischemic cardiomyopathy (ICM) with a reduced left-ventricular ejection fraction (L...
#1Simon G. Anderson (University of Manchester)H-Index: 26
#2Ahmad Shoaib (Keele University)H-Index: 5
Last.Mamas A. Mamas (Keele University)H-Index: 37
view all 10 authors...
Background Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with acute heart failure (AHF). The presence of AF is associated with adverse prognosis in patients with chronic heart failure (CHF) but little is known about its impact in AHF.
#1Bernhard Wernly (University of Salzburg)H-Index: 6
#2Clemens Seelmaier (University of Salzburg)
Last.Ulf Landmesser (Charité)H-Index: 73
view all 11 authors...
Aims Patients suffering from cardiogenic shock (CS) have a high mortality and morbidity. The Impella percutaneous left-ventricular assist device (LVAD) decreases LV preload, increases cardiac output, and improves coronary blood flow. We aimed to review and meta-analyze available data comparing Impella versus intra-aortic pump (IABP) counterpulsation or medical treatment in CS due to acute myocardial infarction or post-cardiac arrest.
#1Elham Kayvanpour (Heidelberg University)H-Index: 13
#2Farbod Sedaghat-Hamedani (Heidelberg University)H-Index: 15
Last.Hugo A. Katus (Heidelberg University)H-Index: 92
view all 11 authors...
Background Left ventricular non-compaction has been increasingly diagnosed in recent years. However, it is still debated whether non-compaction is a pathological condition or a physiological trait. In this meta-analysis and systematic review, we compare studies, which investigated these two different perspectives. Furthermore, we provide a comprehensive overview on the clinical outcome as well as genetic background of left ventricular non-compaction cardiomyopathy in adult patients.
#1Susan Stienen (University of Lorraine)
#2João Pedro Ferreira (University of Lorraine)H-Index: 12
Last.Patrick Rossignol (University of Lorraine)H-Index: 40
view all 10 authors...
Background In patients with acute myocardial infarction (MI), BMI < 18.5 kg/m2 and a decrease in BMI during follow-up have been associated with poor prognosis. For BMI ≥ 25 kg/m2, an “obesity paradox” has been suggested. Recently, high visit-to-visit BMI variability has also been associated with poor prognosis in patients with coronary artery disease.
Background Sympathetic nervous system activation plays a pivotal role in obese patients with obstructive sleep apnea (OSA), contributing to increased cardiovascular risk. Epicardial adipose tissue (EAT) activates cardiac autonomic nervous system. Our main study objective was to investigate effects of these autonomic dysfunction factors on post-exercise heart rate recovery (HRR).
#1Anne Freund (Leipzig University)H-Index: 1
#2Sandra Schock (Leipzig University)
Last.Steffen Desch (Leipzig University)H-Index: 36
view all 8 authors...
Background In the largest randomized trial so far, thrombus aspiration failed to reduce the primary endpoint of microvascular obstruction (MVO) in patients with ST-elevation myocardial infarction (STEMI) presenting late after symptom onset. Long-term clinical outcome data of this trial have not been reported yet.
#1Mark Lipphardt (GAU: University of Göttingen)
#2Michael Koziolek (GAU: University of Göttingen)H-Index: 20
Last.Manuel Wallbach (GAU: University of Göttingen)H-Index: 8
view all 7 authors...
Objective Activation of the sympathetic nervous system increases sodium retention in resistant hypertension. Baroreflex activation therapy (BAT) is an interventional method to reduce sympathetic overactivity in patients with resistant hypertension. This study aimed to assess the effect of BAT on urinary sodium excretion.
#1Sonja Hamed (Heidelberg University)H-Index: 3
#2Schmack Bastian (Heidelberg University)H-Index: 15
Last.Michael M. Kreusser (Heidelberg University)H-Index: 14
view all 9 authors...
Background Ventricular assist devices (VAD) are increasingly used as long-term treatment for advanced heart failure. However, survival after VAD implantation is still unsatisfactory, and no specific outpatient follow-up algorithms have been formally established. Here, we evaluate the effect of an intensified follow-up protocol (IFUP) on survival rates and VAD-associated complications.
#1Alexander JobsH-Index: 6
#2Amr Abdin (RWTH Aachen University)H-Index: 3
Last.Reinhard VontheinH-Index: 22
view all 7 authors...
Aim Major clinical trials have shown that angiotensin-converting enzyme (ACE) inhibitors reduce mortality and morbidity in congestive heart failure (HF). Prior to these seminal findings hemodynamic effects of ACE inhibitors were examined in small studies. We aimed to review these studies systematically and meta-analyze the effects of ACE inhibitors on hemodynamics in HF.
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