High-Throughput Mutation Data Now Complement Transcriptomic Profiling: Advances in Molecular Pathway Activation Analysis Approach in Cancer Biology

We recently reviewed the current progress in the use of high-throughput molecular “omics” data for the quantitative analysis of molecular pathway activation. These quantitative metrics may be used in many ways, and we focused on their application as tumor biomarkers. Here, we provide an update of the most recent conceptual findings related to pathway analysis in tumor biology, which were not included in the previous review. The major novelties...