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Anton Buzdin
Russian Academy of Sciences
92Publications
26H-index
1,775Citations
Publications 93
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Study Objective To develop a prototype of a complex gene expression biomarker for the diagnosis of endometriosis based on differences between molecular signatures of endometrium from women with and without endometriosis. Design Prospective observational cohort study. II-1. Evidence obtained from a well-designed, controlled trial without randomization. Setting Department of Reproductive Medicine and Surgery at the A.I. Evdokimov Moscow State Medical and Dental University. Patients or Participants...
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#1Daniil NikitinH-Index: 3
Last.Anton BuzdinH-Index: 26
view all 9 authors...
Background: Retroelements (REs) are mobile genetic elements comprising ~40% of human DNA. They can reshape expression patterns of nearby genes by providing various regulatory sequences. The proportion of regulatory sequences held by REs can serve a measure of regulatory evolution rate of the respective genes and molecular pathways. Methods: We calculated RE-linked enrichment scores for individual genes and molecular pathways based on ENCODE project epigenome data for enhancer-specific histone mo...
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Background: Transposons are selfish genetic elements that self-reproduce in host DNA. They were active during evolutionary history and now occupy almost half of mammalian genomes. Close insertions of transposons reshaped structure and regulation of many genes considerably. Co-evolution of transposons and host DNA frequently results in the formation of new regulatory regions. Previously we published a concept that the proportion of functional features held by transposons positively correlates wit...
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#1Daniil NikitinH-Index: 3
#2Andrew GarazhaH-Index: 10
Last.Anton BuzdinH-Index: 26
view all 10 authors...
In the article ‘Retroelement—Linked Transcription Factor Binding Patterns Point to Quickly Developing Molecular Pathways in Human Evolution,’ a number of transcription factor binding sites (TFBS) mapped on all retroelement classes were incorrectly calculated as sum of TFBS numbers separately mapped on LINEs, SINEs and LTR retrotransposons/endogenous retroviruses (LR/ERVs) [...]
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#1Ivana JovčevskaH-Index: 3
#2Alja ZottelH-Index: 2
Last.Radovan KomelH-Index: 29
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World Health Organization grade IV diffuse gliomas, known as glioblastomas, are the most common malignant brain tumors, and they show poor prognosis. Multimodal treatment of surgery followed by radiation and chemotherapy is not sufficient to increase patient survival, which is 12 to 18 months after diagnosis. Despite extensive research, patient life expectancy has not significantly improved over the last decade. Previously, we identified FREM2 and SPRY1 as genes with differential expression in g...
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#1Ella L. Kim (University of Mainz)H-Index: 7
#2Anton BuzdinH-Index: 26
Last.Alf GieseH-Index: 26
view all 10 authors...
e13533Background: This study developed molecular guided tools for individualized selection of chemotherapeutics for recurrent glioblastoma (rGB). A consortium involving clinical neurooncologists, m...
1 CitationsSource
#1Anton BuzdinH-Index: 26
#2Andrew GarazhaH-Index: 10
Last.Nurshat Gaifullin (MSU: Moscow State University)H-Index: 8
view all 11 authors...
e13032Background: Intracellular molecular pathways (IMPs) control all major events in the living cell. They are considered hotspots in contemporary oncology because knowledge of IMPs activation is ...
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#1Elena PoddubskayaH-Index: 6
#2Anton BuzdinH-Index: 26
Last.Nikolay M. Borisov (MSMU: I.M. Sechenov First Moscow State Medical University)H-Index: 14
view all 17 authors...
e13143Background: Anticancer Targeted Drugs (ATDs) specifically target one or a few types of tumor-related molecules in a cell. More than two hundred of ATDs were approved worldwide. They have diff...
1 CitationsSource
#1Daniil NikitinH-Index: 3
#2Andrew GarazhaH-Index: 10
Last.Anton BuzdinH-Index: 26
view all 10 authors...
Background: Retroelements (REs) are transposable elements occupying ~40% of the human genome that can regulate genes by providing transcription factor binding sites (TFBS). RE-linked TFBS profile can serve as a marker of gene transcriptional regulation evolution. This approach allows for interrogating the regulatory evolution of organisms with RE-rich genomes. We aimed to characterize the evolution of transcriptional regulation for human genes and molecular pathways using RE-linked TFBS accumula...
5 CitationsSource
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