Human dihydrofolate reductase is a substrate of protein kinase CK2α
Volume: 513, Issue: 2, Pages: 368 - 373
Published: May 1, 2019
Abstract
Dihydrofolate reductase (DHFR) is a prominent molecular target in antitumor, antibacterial, antiprotozoan, and immunosuppressive chemotherapies, and CK2 protein kinase is an ubiquitous enzyme involved in many processes, such as tRNA and rRNA synthesis, apoptosis, cell cycle or oncogenic transformation. We show for the first time that CK2α subunit strongly interacted with and phosphorylated DHFR in vitro. Using quartz crystal microbalance with...
Paper Details
Title
Human dihydrofolate reductase is a substrate of protein kinase CK2α
Published Date
May 1, 2019
Volume
513
Issue
2
Pages
368 - 373
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