Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition
Abstract
Most next generation sequencing (NGS) studies identified candidate genetic variants predisposing to colorectal cancer (CRC) but do not tackle its functional interpretation to unequivocally recognize a new hereditary CRC gene. Besides, germline variants in already established hereditary CRC-predisposing genes or somatic variants share the same need when trying to categorize those with relevant significance. Functional genomics approaches have an...
Paper Details
Title
Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition
Published Date
Oct 1, 2019
Volume
69
Pages
27 - 40
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