A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
Abstract
Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to map the molecular dependencies of pancreatic cancer stem cells, highly therapy-resistant cells that preferentially drive tumorigenesis and progression. This integrated genomic approach revealed an unexpected utilization of immuno-regulatory signals by...
Paper Details
Title
A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
Published Date
Apr 1, 2019
Journal
Volume
177
Issue
3
Pages
572 - 586.e22
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