AKT1low quiescent cancer cells in ductal carcinoma in situ of the breast
Abstract
Ductal carcinoma in situ (DCIS) of the breast precedes the development of invasive breast cancer and reflects the genomic changes and protein expression profile of invasive disease. AKT1low cancer cells (QCC) are a rare, drug-tolerant, epigenetically plastic, and quiescent cancer cell subset that we previously identified at a frequency of 0.5-1% in primary breast tumors using the marker profile: AKTlow/H3K9me2low/HES1high. Here we used...
Paper Details
Title
AKT1low quiescent cancer cells in ductal carcinoma in situ of the breast
Published Date
Mar 21, 2019
Journal
Volume
5
Issue
1
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