Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm
Abstract
Sequencing and the single sperm During meiosis, homologous chromosomes undergo doublestrand breaks in DNA that can cross over, shuffling genetic material. However, not every double-strand break resolves in a crossover event. Hinch et al. wanted to determine the rules governing DNA recombination. They developed a method to sequence individual mouse sperm and applied it to mice carrying two different alleles of a protein involved in mammalian...
Paper Details
Title
Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm
Published Date
Mar 22, 2019
Journal
Volume
363
Issue
6433
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