Peter Donnelly
University of Oxford
Genome-wide association studyGenetic associationPopulationGeneticsBiology
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Publications 480
#1Gretchen KerrH-Index: 16
#2Bruce KiddH-Index: 11
Last. Peter DonnellyH-Index: 95
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Millions of children and adolescents around the world participate in organized sport for holistic health and developmental benefits. However, for some, sport participation is characterized by experiences of maltreatment, including forms of abuse and neglect. In Canada, efforts to address and prevent maltreatment in sport have been characterized by recurring cycles of crisis, public attention, policy response, sluggish implementation, and active resistance, with very little observable change. The...
#1Linda SharpH-Index: 33
#2Eila WatsonH-Index: 36
Last. Jo BrettH-Index: 18
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#1Ellen Stewart (Edin.: University of Edinburgh)H-Index: 7
Last. Peter DonnellyH-Index: 95
view all 4 authors...
Abstract Arms' length bodies are often seen as a tool of technocratic governance, designed to insulate decision-making from the politicizing pressures of populist influence. This article examines a subset of arms' length bodies in the UK which challenge this convention: agencies which exist to 'champion' the voice of patients and the public in the four NHS systems (England, Northern Ireland, Scotland and Wales). We compare the functions of these agencies on paper and through qualitative intervie...
#1Melody E. Morton Ninomiya (WLU: Wilfrid Laurier University)
Last. Vicky StergiopoulosH-Index: 19
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Background: Mental health, substance use/addiction and violence (MSV) are important issues affecting the well-being of Indigenous People in Canada. This paper outlines the protocol for a research-to-action program called the Mental Wellness Program (MWP). The MWP aims to increase community capacity, promote relationship-building among communities, and close gaps in services through processes that place value on and supports Indigenous communities' rights to self-determination and control. The MW...
#1Riccardo A. AudisioH-Index: 33
#2Peter DonnellyH-Index: 95
Last. Janet A. DunnH-Index: 45
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#1Meghan O’Neill (U of T: University of Toronto)H-Index: 2
#2Emmalin Buajitti (U of T: University of Toronto)H-Index: 1
Last. Laura C. RosellaH-Index: 24
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Background Homicide is an extreme expression of violence that has attracted less attention from public health researchers and policy makers interested in prevention. The purpose of this study was to examine the socioeconomic gradient of homicide and to determine whether risk differs by immigration status. Methods We conducted a population-based cohort study using linked vital statistics, census and population data sets that included all deaths by homicide from 1992 to 2012 in Ontario, Canada. We...
#1Daniel Wells (University of Oxford)H-Index: 4
#2Emmanuelle Bitoun (University of Oxford)H-Index: 11
Last. Simon Myers (University of Oxford)H-Index: 41
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During meiosis, homologous chromosomes pair (synapse) and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, recombination initiates with double-strand breaks (DSBs) within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising this unique combination of histone marks have yet been identified. We identified Zcwpw1, which possesses H3K4me3 and H3K36me3 recognition domains, as highly co-expressed with Prdm9. He...
2 CitationsSource
#1Peter Donnelly (U of T: University of Toronto)H-Index: 30
#1Peter Donnelly (U of T: University of Toronto)H-Index: 95
Last. Colleen Grogan (U of T: University of Toronto)
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#1Mohammad Shahzad (U of T: University of Toronto)
#2Ross E. G. Upshur (U of T: University of Toronto)H-Index: 47
Last. Terrence Sullivan (U of T: University of Toronto)H-Index: 25
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A population-based approach to healthcare goes beyond the traditional biomedical model and addresses the importance of cross-sectoral collaboration in promoting health of communities. By establishing partnerships across primary care (PC) and public health (PH) sectors in particular, healthcare organizations can address local health needs of populations and improve health outcomes. The purpose of this study was to map a series of interventions from the empirical literature that facilitate PC-PH c...
#1Rory Bowden (University of Oxford)H-Index: 36
#2Robert W. Davies (The Centre for Applied Genomics)H-Index: 15
Last. Peter Donnelly (University of Oxford)H-Index: 95
view all 20 authors...
Whole-genome sequencing (WGS) is becoming widely used in clinical medicine in diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the Oxford Nanopore Technologies (ONT) MinION long-read sequencer for routine WGS by sequencing the reference sample NA12878 and the genome of an individual with ataxia-pancytopenia syndrome and severe immune dysregulation. We develop and apply a novel reference panel-free analytical method to infer and then exploit phase information ...
2 CitationsSource