Restoration of endothelial autophagic flux in vascular endothelial cells exposed to low shear stress

Atherosclerotic lesions develop in arterial areas exposed to low shear stress (SS) like aortic arch where endothelial cells express a pro-inflammatory and pro-senescent phenotype. Our team has shown that defective endothelial autophagy favours an atheroprone phenotype. Previous studies have stated that stabilised microtubules, a function of various post-translational modifications, facilitate efficient fusion of autophagosomes and lysosomes, a...