Chantal M. Boulanger
Paris Descartes University
Publications 202
#1Franziska Kenneweg (MHH: Hannover Medical School)H-Index: 2
#2Claudia Bang (MHH: Hannover Medical School)H-Index: 14
Last.Thomas Thum (MHH: Hannover Medical School)H-Index: 66
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Abstract Long non-coding RNAs (lncRNAs) have the potential as novel therapeutic targets in cardiovascular diseases. But detailed information about the intercellular lncRNA shuttling mechanisms in the heart is lacking. Here we report an important novel crosstalk between cardiomyocytes and fibroblasts mediated by the transfer of lncRNA-enriched extracellular vesicles (EVs) in the context of cardiac ischemia. LncRNA profiling identified two hypoxia-sensitive lncRNAs: ENSMUST00000122745 was predomin...
Abstract Background Left atrial appendage occlusion (LAAO) has emerged as a valid alternative to oral anticoagulation therapy for the prevention of systemic embolism in patients with non-valvular atrial fibrillation (NVAF). Microvesicles (MVs) are shed-membrane particles generated during various cellular types activation/apoptosis that carry out diverse biological effects. LAA has been suspected to be a potential source of MVs during AF, but the effects its occlusion on circulating MVs levels ar...
#1S.M.I. Mazlan (French Institute of Health and Medical Research)
#2V Duval (French Institute of Health and Medical Research)
Last.Xavier Loyer (French Institute of Health and Medical Research)H-Index: 23
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Introduction Cardiovascular disease (CVD) is the main cause of death in non-communicable diseases. In response to myocardial infarction (MI), extracellular vesicles (EVs) including large (lEVs) and small (sEVs), are released within and from the heart to facilitate intercellular communication and maintaining cardiac homeostasis. Objective As diabetes increases the risk of CVD, the purpose of the study was to investigate how diabetes influences the release of intracardiac EVs after MI. Method C57B...
Introduction Atherosclerotic lesions develop in arterial areas exposed to low shear stress (SS) like aortic arch where endothelial cells express a pro-inflammatory and pro-senescent phenotype. Our team has shown that defective endothelial autophagy favours an atheroprone phenotype. Objective Previous studies have stated that stabilised microtubules, a function of various post-translational modifications, facilitate efficient fusion of autophagosomes and lysosomes, a critical step in autophagy. I...
#1P.M. Coly (French Institute of Health and Medical Research)
#2S. Chatterjee (French Institute of Health and Medical Research)
Last.Chantal M. Boulanger (French Institute of Health and Medical Research)H-Index: 58
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Introduction Atherosclerotic lesions mainly form in areas exposed to low shear stress (LSS), where endothelial cells express a senescent and inflammatory phenotype. Endothelial autophagy is a protective process, stimulated under conditions of high shear stress (HSS, 20 dyn/cm2) when compared to LSS (2 dyn/cm2), and hampers the development these lesions. Objective While previous studies have shown links between autophagy and extracellular vesicle (EV) formation, the precise role of the autophagic...
#1André Görgens (University of Duisburg-Essen)H-Index: 9
#2Michel Bremer (University of Duisburg-Essen)H-Index: 5
Last.Bernd Giebel (University of Duisburg-Essen)H-Index: 32
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ABSTRACTExtracellular vesicles (EVs) mediate targeted cellular interactions in normal and pathophysiological conditions and are increasingly recognised as potential biomarkers, therapeutic agents a...
8 CitationsSource
1 CitationsSource
#1Audrey Payancé (Paris Diderot University)H-Index: 5
Last.Pierre-Emmanuel Rautou (French Institute of Health and Medical Research)H-Index: 33
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4 CitationsSource