Original paper
DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation
Abstract
Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. We recently showed that DNAJB3 co-chaperone is downregulated in obese and diabetic patients and that physical exercise restores its normal expression with a significant improvement of the clinical outcomes. In 3T3-L1 adipocytes, DNAJB3 has a role in improving the sensitivity to insulin and glucose uptake. In co-immunoprecipitation assays,...
Paper Details
Title
DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation
Published Date
Mar 18, 2019
Journal
Volume
9
Issue
1
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Notes
History