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Comparison of plasma levels of different species of trans fatty acids in Japanese male patients with acute coronary syndrome versus healthy men

Published on May 1, 2019in Atherosclerosis4.255
· DOI :10.1016/j.atherosclerosis.2019.02.025
Shinji Koba26
Estimated H-index: 26
(Showa University),
Tetsuya Takao2
Estimated H-index: 2
(Showa Women's University)
+ 8 AuthorsAkikazu Takada32
Estimated H-index: 32
Abstract
Abstract Background and aims It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. Methods Plasma fatty acid (FA) composition (as determined by gas chromatography) was analyzed in ACS patients on hospital admission and compared to that of age-adjusted healthy men. Results Total FA and TFA levels were similar between ACS and control subjects. Palmitelaidic acid, ruminant-derived TFA (R-TFA), levels were lower in ACS patients (0.17 ± 0.06 vs. 0.20 ± 0.06 of total FA, in ACS and control, respectively, p Conclusions There were several case-control differences in specific TFA that could potential affect risk for ACS. Japanese ACS patients, especially middle-aged patients, may consume less R-TFA.
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  • Citations (1)
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#1Naohiro Gotoh (Tokyo University of Marine Science and Technology)H-Index: 19
#2Kazuaki YoshinagaH-Index: 8
Last. Koji Nagao (Saga University)H-Index: 27
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#1Yuri Shijo (Japan Women's University)H-Index: 2
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Background Limited evidence has suggested that circulating levels of the omega-9 fatty acid, oleic acid, may be related to greater risks of adverse cardiovascular outcomes. Objective We aimed to determine whether plasma oleic acid may be independently associated with clinical and subclinical cardiovascular disease (CVD) and all-cause mortality in a large multiethnic cohort. Methods Plasma fatty acids were measured by gas chromatography–flame ionization in 6568 participants of the Multi-Ethnic St...
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#1Makoto Kinoshita (Toray Industries)H-Index: 1
#2Koutaro Yokote (Chiba University)H-Index: 36
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#1Fumiko ShimizuH-Index: 2
#2Ishii YH-Index: 2
Last. Akikazu TakadaH-Index: 32
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Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of trans fatty acids in the foods is prohibited, thus trans fatty acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty acids including trans forms of healthy old men are measured by gas chromatography and correlations between various foods intak...
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#1Akikazu TakadaH-Index: 32
#2Fumiko ShimizuH-Index: 2
Last. William S. HarrisH-Index: 48
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Background: Coronary heart disease (CHD) rates differ markedly between the US and Japan. Fatty acid profiles have been linked to risk for CHD. Few studies have compared the plasma fatty acid composition, including trans fatty acids, in Japanese and US subjects. Methods: Fasting blood samples were taken from healthy older (>age 50) American (n = 76) and Japanese (n = 44) men, and plasma levels of 23 fatty acids were analyzed by gas chromatography and expressed as a percent of total fatty acids. R...
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#1Kiyotaka Itcho (Hiroshima University)H-Index: 5
#2Yoko Yoshii (Hiroshima University)H-Index: 4
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Many cohort studies have shown that increased trans fatty acid (TFA) intake increases the risk of developing coronary heart disease. However, whether TFA intake is directly associated with the development of diabetes mellitus (DM) remains unknown.We performed the 75-g oral glucose tolerance test in two Japanese cohorts: a cohort of 454 native Japanese living in Hiroshima, Japan, and a cohort of 426 Japanese-Americans living in Los Angeles, USA, who shared identical genetic predispositions but ha...
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Background Trans-fatty acids (TFAs) occur in small amounts in nature but became widely produced by the food industry. The hazardous effects of different TFA subtypes to human health are controversial. We aimed to evaluate the association of plasma TFAs levels (elaidic acid, vaccenic acid, palmitelaidic acid, and linoelaidic acid) with mortality.
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#1Hiroyuki Takeuchi (Toyama College)H-Index: 19
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Trans fatty acid (TFA) from partially hydrogenated oil is regarded as the worst dietary fatty acid per gram due to its role in coronary heart disease. TFA consumption is decreasing worldwide, but some but not all observational studies indicate that TFA intake has little relevance to serum cholesterol levels in populations with low TFA intake (<1% E [percentage of total energy intake],
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Abstract We conducted a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of industrial trans fatty acids (iTFA) and increased low-density lipoprotein cholesterol (LDL-C). Previous regression analyses included insufficient data to determine the nature of the dose response in the low-dose region and have nonetheless assumed a linear relationship between iTFA intake and LDL-C levels. This work contributes to the previous work by...
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