Match!

Comparison of plasma levels of different species of trans fatty acids in Japanese male patients with acute coronary syndrome versus healthy men

Published on May 1, 2019in Atherosclerosis4.25
· DOI :10.1016/j.atherosclerosis.2019.02.025
Shinji Koba25
Estimated H-index: 25
(Showa University),
Tetsuya Takao2
Estimated H-index: 2
(Showa Women's University)
+ 8 AuthorsAkikazu Takada32
Estimated H-index: 32
Cite
Abstract
Abstract Background and aims It remains unclear how trans fatty acid (TFA) at low-level intake affect lipid levels and the development of acute coronary syndrome (ACS). The study aimed to investigate how plasma TFA composition differs between male patients with ACS and healthy men. Methods Plasma fatty acid (FA) composition (as determined by gas chromatography) was analyzed in ACS patients on hospital admission and compared to that of age-adjusted healthy men. Results Total FA and TFA levels were similar between ACS and control subjects. Palmitelaidic acid, ruminant-derived TFA (R-TFA), levels were lower in ACS patients (0.17 ± 0.06 vs . 0.20 ± 0.06 of total FA, in ACS and control, respectively, p 0.01), and were significantly directly associated with HDL cholesterol (HDL-C) (rho = 0.269) and n-3 polyunsaturated FA (n-3 PUFA) (rho = 0.442). Linoleic trans isomers (total C18:2 TFA), primary industrially-produced TFA (IP-TFAs), were significantly higher in ACS patients (0.68 ± 0.17 vs . 0.60 ± 0.20 of total FA, in ACS and control, respectively). Total trans -C18:1 isomers were comparable between ACS and control. Differences between ACS and controls in C18:1 trans varied by specific C18:1 trans species. Absolute concentrations of trans -C18:2 isomers were significantly directly associated with LDL-C and non-HDL-C in ACS men. The ACS patients showed significantly lower levels of both n-6 and n-3 PUFA (i.e., eicosapentaenoic, docosahexaenoic and arachidonic acids). Conclusions There were several case-control differences in specific TFA that could potential affect risk for ACS. Japanese ACS patients, especially middle-aged patients, may consume less R-TFA.
  • References (39)
  • Citations (0)
Cite
References39
Newest
Published on Jan 1, 2019in Journal of Oleo Science1.21
Naohiro Gotoh19
Estimated H-index: 19
(Tokyo University of Marine Science and Technology),
Kazuaki Yoshinaga8
Estimated H-index: 8
+ 7 AuthorsKoji Nagao27
Estimated H-index: 27
(Saga University)
Published on Jan 1, 2019in Journal of Atherosclerosis and Thrombosis3.48
Yuri Shijo2
Estimated H-index: 2
(Japan Women's University),
Chizuko Maruyama13
Estimated H-index: 13
(Japan Women's University)
+ 7 AuthorsSatomi Hirai2
Estimated H-index: 2
(Japan Women's University)
Published on Nov 1, 2018in Journal of Clinical Lipidology3.58
Brian T. Steffen13
Estimated H-index: 13
(UMN: University of Minnesota),
Daniel Duprez43
Estimated H-index: 43
(UMN: University of Minnesota)
+ 2 AuthorsMichael Y. Tsai55
Estimated H-index: 55
(UMN: University of Minnesota)
Background Limited evidence has suggested that circulating levels of the omega-9 fatty acid, oleic acid, may be related to greater risks of adverse cardiovascular outcomes. Objective We aimed to determine whether plasma oleic acid may be independently associated with clinical and subclinical cardiovascular disease (CVD) and all-cause mortality in a large multiethnic cohort. Methods Plasma fatty acids were measured by gas chromatography–flame ionization in 6568 participants of the Multi-Ethnic St...
Published on Sep 1, 2018in Journal of Atherosclerosis and Thrombosis3.48
Makoto Kinoshita1
Estimated H-index: 1
(Toray Industries),
Koutaro Yokote35
Estimated H-index: 35
(Chiba University)
+ 29 AuthorsTomonori Okamura48
Estimated H-index: 48
(Keio: Keio University)
Published on Jan 1, 2018in Food and Nutrition Sciences
Akikazu Takada32
Estimated H-index: 32
,
Akikazu Takada1
Estimated H-index: 1
+ 5 AuthorsWilliam S. Harris74
Estimated H-index: 74
Background: Coronary heart disease (CHD) rates differ markedly between the US and Japan. Fatty acid profiles have been linked to risk for CHD. Few studies have compared the plasma fatty acid composition, including trans fatty acids, in Japanese and US subjects. Methods: Fasting blood samples were taken from healthy older (>age 50) American (n = 76) and Japanese (n = 44) men, and plasma levels of 23 fatty acids were analyzed by gas chromatography and expressed as a percent of total fatty acids. R...
Published on Jan 1, 2018in Food and Nutrition Sciences
Fumiko Shimizu1
Estimated H-index: 1
,
Yukie Ishii1
Estimated H-index: 1
+ 3 AuthorsAkikazu Takada32
Estimated H-index: 32
Background: Trans fatty acids are said to be formed by the partial hydrogenation of vegetable oils. Some amounts are produced in digestive organs of ruminants and present in dairy products or meat. In Japan, use of trans fatty acids in the foods is prohibited, thus trans fatty acids must come from foods or microbes in the digestive organs. Methods: Plasma levels of fatty acids including trans forms of healthy old men are measured by gas chromatography and correlations between various foods intak...
Published on Dec 1, 2017in Lipids in Health and Disease2.65
Haibo Li1
Estimated H-index: 1
(Wannan Medical College),
Qian Zhang1
Estimated H-index: 1
(Anhui Medical University)
+ 4 AuthorsYufeng Wen1
Estimated H-index: 1
(Wannan Medical College)
Background Trans-fatty acids (TFAs) occur in small amounts in nature but became widely produced by the food industry. The hazardous effects of different TFA subtypes to human health are controversial. We aimed to evaluate the association of plasma TFAs levels (elaidic acid, vaccenic acid, palmitelaidic acid, and linoelaidic acid) with mortality.
Published on Jan 1, 2017in Journal of Atherosclerosis and Thrombosis3.48
Kiyotaka Itcho4
Estimated H-index: 4
(Hiroshima University),
Yoko Yoshii4
Estimated H-index: 4
(Hiroshima University)
+ 7 AuthorsMasayasu Yoneda11
Estimated H-index: 11
(Hiroshima University)
Published on Jan 1, 2017in Journal of Lipids
Hiroyuki Takeuchi19
Estimated H-index: 19
,
Michihiro Sugano53
Estimated H-index: 53
Trans fatty acid (TFA) from partially hydrogenated oil is regarded as the worst dietary fatty acid per gram due to its role in coronary heart disease. TFA consumption is decreasing worldwide, but some but not all observational studies indicate that TFA intake has little relevance to serum cholesterol levels in populations with low TFA intake (<1% E [percentage of total energy intake],
Published on Dec 1, 2016in Food and Chemical Toxicology3.77
Bruce C. Allen23
Estimated H-index: 23
,
Melissa J. Vincent3
Estimated H-index: 3
+ 1 AuthorsLynne T. Haber18
Estimated H-index: 18
Abstract We conducted a meta-regression of controlled clinical trial data to investigate quantitatively the relationship between dietary intake of industrial trans fatty acids (iTFA) and increased low-density lipoprotein cholesterol (LDL-C). Previous regression analyses included insufficient data to determine the nature of the dose response in the low-dose region and have nonetheless assumed a linear relationship between iTFA intake and LDL-C levels. This work contributes to the previous work by...
Cited By0
Newest
View next paperErythrocyte membrane trans-fatty acid index is positively associated with a 10-year CHD risk probability.