Original paper
Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection
Volume: 116, Issue: 13, Pages: 6091 - 6100
Published: Mar 8, 2019
Abstract
In the repair of DNA double-strand breaks by homologous recombination, the DNA break ends must first be processed into 3' single-strand DNA overhangs. In budding yeast, end processing requires the helicase Sgs1 (BLM in humans), the nuclease/helicase Dna2, Top3-Rmi1, and replication protein A (RPA). Here, we use single-molecule imaging to visualize Sgs1-dependent end processing in real-time. We show that Sgs1 is recruited to DNA ends through...
Paper Details
Title
Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection
Published Date
Mar 8, 2019
Volume
116
Issue
13
Pages
6091 - 6100
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Notes
History